Dsquared2 is a Canadian fashion brand created by twin brothers Dean and Dan Caten. The brothers studied at Parsons School of Design briefly before diving into the world of full-time fashion, serving as creative directors of Ports in 1961.

The brothers went to Italy in 1991 with the dream of creating their own line. Design work for Versace and Diesel eventually led to their first men's clothing collection under the Dsquared2brand, which made its debut in Milan, with the financial backing provided by Diesel. The success of her menswear collection allowed the expansion of women's clothing, with her first women's collection introduced in 2002. Her first women's collection earned them praise and a front-page feature in "Women's Wear Daily".

In 2002, the couple also signed a licensing agreement that expanded the brand's offerings on footwear, accessories and fragrances.

The Dsquared2 brand is known for its extravagant and energetic fashion shows, many of which feature musicians and celebrities such as Rihanna and Christina Aguilera making a unique entrance and walk along the catwalk. The couple's designs have loyal celebrity fans and clothing often appears in music videos or between costumes for a world tour. Madonna commissioned the couple to design the costumes for their 2002 "Drowned World" tour, and Britney Spears included Dsquared2 clothing on her Circus tour in 2009.

Dsquared2 has won numerous fashion awards, including the Golden Needle (Spain), La Kore (Italy) and the Innovative Design Team of GQ magazine and Men of the Year (both for GQ Spain and for the US edition).

The Dsquared2 brand offered its first fragrance in 2007, He Wood. Women's partner She Wood was released in 2008. Dsquared2 fragrances are produced in conjunction with the ITF Group.